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Menthol also interacts with nicotine in the brain to enhance the addictiveness of nicotine, making it harder for people to quit smoking, explained Rachel Grana Mayne, Ph.D., a program director in NCI's Tobacco Control Research Branch

Atherosclerotic cardiovascular disease, or ASCVD, involves plaque buildup in artery walls which includes conditions such as acute coronary syndrome and peripheral artery disease, and can cause a heart attack, stable or unstable angina, stroke, transient ischemic attack or aortic aneurysm

This effect is consistent with literature on the effects of packaging color on product perceptions of attractiveness, taste, and health risks [3133]