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In the long term, smoking narrows the airways and causes damage to the lungs that limits the amount of oxygen in the body at all times." While the cardiovascular system is worst hit, there is some evidence that long-term smoking also leads to a decrease in muscle strength and volume of muscle fibres, affecting both speed and power

This makes cannabidiol an active area of research for CBD in cannabis use disorder treatment, helping patients reduce THC cravings and manage withdrawal discomfort

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Surgeon General concluded that secondhand smoke was a major health risk to nonsmokers

Cocaine and nicotine/tobacco were found to have intermediary MOE values