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Although the 1964 Surgeon Generals Report on Smoking and Health criticized candy cigarette makers for trying to lure youngsters to the smoking habit, the sale of these products to children went unchallenged until the 1980s when pressure and adverse publicity generated by organizations such as DOC (Doctors Ought to Care) led tobacco companies to protect their cigarette brands from being used by candy companies

A predominance of pro-inflammatory M1 cells was found in the small airways, whereas M2 macrophages dominated in the luminal areas

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