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It leads to changes in the structure of skin matrix proteins, such as collagen and elastin, and consequently, to loss of skin elasticity and firmness, the formation of wrinkles, and pigmentation disorders (116118)

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This reflects a proactive approach to replace or upgrade aging facilities (based on factors like foot traffic, sales, and store age) to keep pace with industry trends

or had a body mass index (BMI) of less than 18 kg/m 2 or greater than 40 kg/m 2

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