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Given that it is widely accepted that the disruption of the relationship between microbiota and intestinal mucosa is one of the main contributors to the pathophysiology of CD, the impact of cigarette smoking on the microbiota can have a great impact in the onset of this disease (Figure 1)

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The follow-up for the cotton workers cohort was for 42 years and age at entry covered the full age range from less than 20 years to over 70 years