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Smoking is injurious to health

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In accordance with these results, upregulation of filaggrin was also observed in oral keratinocytes of smokers 19 , in keratinocyte cell cultures 19, 20 or in reconstructed human epidermis 21 exposed to cigarette smoke extract, and porcine skin explants exposed to cigarette smoke (our unpublished data)

They found James Whales work too outrageous for the film and he was taken off the project where it was then given to Lambert Hilyard who had been working on westerns

However, its important to note that it may not be the only cause