If you're looking to give up smoking we recommend choosing a higher strength nic salt initially (50mg like a JUUL), you can slowly reduce the nicotine levels once you are smoke-free
For example, it states: Consistent with the FDAs risk-based approach to evaluating whether marketing a product meets the APPH standard, the extent of evidence needed to demonstrate sufficient adult benefit may vary based on the relative magnitude of youth risks posed by the products flavor characteristics
Alexander (Sandie) Pendleton discusses the issue and its potential impact on rural communities in the state
Air pollution, genetic factors, and the risk of lung cancer: a prospective study in the UK biobank
CS exposure activates the pro-inflammatory transcription factor nuclear factor kappa B (NF-B) and increases messenger RNA (mRNA) expression of IL-8 (one of the mediators controlled by NF-B) within the macrophages.21 22 This process is at least partially an autologous effect, with other cells such as bronchial epithelial cells shown to release increased IL-8 in response to CS that would contribute to stimulate macrophage and neutrophil influx.23 The increased BALF cellularity may take over 1 month to significantly reduce and up to 6 months to fully normalise.24 Accumulation of autofluorescent bodies AMs from smokers contain autofluorescent bodies25 due to the uptake of CS particles (ie, tar)
