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Similarly, overexpression of IRAK-M (a negative regulator of TLR-mediated immune responses) in human macrophages through JAK2/STAT3/PI3K not only mediates the anti-inflammatory effect of nicotine via 7nAChRs but also triggers the hyperresponsivity [134]

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Time: 90s, year 1996 Place: san francisco, los angeles, usa, oakland california, toronto ontario canada