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Interestingly, the p16 senescence pathway can promote AT2 proliferation and regeneration through IGF1/Akt signaling in emphysema [79], highlighting that senescence-associated pathways may have context-dependent effects, including compensatory or maladaptive regeneration

Nevertheless, the possibility warrants patients' monitoring for clinical and therapeutical evaluation if neuropsychiatric symptoms occur, including behavioral changes, hostility, agitation, depressive mood, suicidal ideation

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The Constitutional Court of Georgia delivered its decision on the unconstitutionality of universal ban on weed consumption in July 2018