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Sirius red staining in rat liver, where the red colour indicates collagen deposition FD&C Green #3 In a 1977 study quoted by the CSPI report, FD&C Green #3 at high dosages yielded several pathological changes in animals

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Step 1 examines the product and its aerosol, Step 2 understands its effects using laboratory models, Step 3 learns about the effects in smokers who switch, Step 4 studies how people perceive and use the product, and Step 5 observes its impact on population health and/or over the long term

in human physiology