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In LPS and oxygen-glucose deprivation -induced inflammation models of microglia N9 cells, -CBT-diol promoted a neuroprotective tilt of microglia activation by down-regulating levels of NF-B/iNOS, a marker of M1 inflammatory response, and up-regulating levels of Arg-1 and IL-10, markers of M2 anti-inflammatory activation

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HTPs first arrived in US markets in the 1980s with the introduction of Premier (1988), followed by Eclipse (1996), Accord (1998), and Revo (2014) (2)