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[12] Tobacco-specific impurities such as cotinine, nicotine-N'-oxides ( cis and trans isomers), and beta-nornicotyrine are believed to be the result of bacterial action or oxidation during the extracting of nicotine from tobacco

And this was only the beginning of a long process that tobacco companies fought tooth and nail

Greater emphasis on transparency: As consumers become more discerning, online cigarette retailers may need to provide more detailed information about their products origins and manufacturing processes

Pharmacol Biochem Behav 59(2):313318

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