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The sale and marketing of snus have been prohibited in the UK since 1992 under the EU Tobacco Products Directive (TPD), retained post-Brexit, and reinforced in 2016 by the Tobacco and Related Products Regulations (TRPR)

Dose-response relationship between O 6 -methylguanine formation in Clara cells and induction of pulmonary neoplasia in the rat by 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone