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It binds the ingredients together and keeps the pouch cohesive, while remaining gentle on oral tissue

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(2019) demonstrated that oral administration of 1-(N-methyl-N-nitrosamino)-1-(3-pyridinyl)-4-butanal (NNA), a major component of tobacco-specific nitrosamines to premature female mice resulted in a significant decrease of ovary weight, ovarian follicle number and survival of superovulated oocytes