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Effect of cigarette smoking on serum testosterone level among male smokers: a cross-sectional study

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In fact, the distal segment of the large intestine can be affected mainly by the circulating components, where both CO and nicotine could modulate the inflammatory profile and leukocyte migration, and the immunomodulatory role would prevail over the impact on the mucosa (Figure 2)

Additionally, mitochondrial reactive oxygen species (ROS) can directly stimulate changes in alveolar epithelial cells, causing them to adopt a profibrotic phenotype (Larson-Casey et al., 2020