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About half of former smokers have trouble sleeping while theyre trying to quit

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Over time this can lead to a reduction in the number of nicotine receptors in the brain - and it is the large number of these receptors in smokers that contributes to withdrawal because the activation of these receptors is what triggers the effects of nicotine

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Patients with alcohol or opioid dependence report several barriers to quitting smoking tobacco including anxiety, tension/irritability, and concerns about the ability to maintain abstinence from their primary substance of abuse (McHugh et al ., 2017)