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Specifically, nicotine and its primary metabolite cotinine are metabolized by the uridine 5-diphospho-glucuronosyltransferase (UGT) superfamily enzymes: specifically UGT2B10 for nicotine and cotinine, and UGT2B7, UGT2B15, and UGT2B17 are responsible for metabolizing androgens

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The increased latency to leave the open arm on escape 2 was negatively correlated, when data from the control and TFC-exposed rats were analysed together, with increases in the levels of SOD (r = 0.54, p = 0.03) and catalase (r = 0.60, p = 0.018), TBARS (r = 0.58, p = 0.02) and in the number of neutrophils in the BALF (r = 0.54, p = 0.036)

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