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Short answer: definitely

In fact, nicotine is just one of about 7,000 chemicals in cigarette smoke, of which at least 250 are known to be harmful, including hydrogen cyanide, carbon monoxide, and ammonia

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Purpose-built for physicians Smoking a marker for lower rates of BP control in patients with hypertension Smoking cigarettes was associated with lower rates of BP control among patients on medication to treat hypertension, according to an abstract presented at the American College of Cardiology Latin America Conference