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Additionally, nicotine exposed mice show upregulated expression of VCAM-1, COX-2, platelet-derived growth factor (PDGF), and molecules involved in downstream of NF-B signaling pathway in aorta lesions [279]

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Diagnosis of nicotine dependence predicts inter-age increases in SmPEGS in these two groups even after controlling for accumulation in pack-years between 26 and 38, suggesting the SmPEGS indexes physical aspects of smoking behavior above and beyond volume of cigarette consumption

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Have I checked the product version and pack details