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Smoking affects the brain in numerous ways, with the nicotine directly activating neurotransmitters to release dopamine and other chemicals that interfere with the subcortical brain regions

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Interestingly, addition of PTIO, a scavenger of nitric oxide (NO) showed slight but significant inhibition of the cell death suggesting the role for combustion-mediated generation of NO in smoke-dependent cell death induction in plant cells (Figure 5)

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