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It is also recognized that smoke exposure leads to the activation of the Nod-like receptor protein 3 (NLRP3) inflammasome [63], with consequent local generation of active interleukin 1 (IL-1), a process that induces inflammation and thereby can lead to both chronic fibrosis and cancer in mice [64]

It can also sometimes affect people with hypothyroidism, though this is not common

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This eliminates the symptoms of withdrawal that may trigger smoking

Other countries, such as Argentina, Chile, and Peru, have smaller market sizes (ranging from $126 million to $67 million), but user penetration is gradually increasing