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The study reinforces an important public-health message: older smokers should not be excluded from tobacco control strategies simply because of their age

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Oral / transdermal route avoids hepatic first-pass and produces lower clotting-factor induction than oral estrogen FDA label status / Vivelle-Dot label lists smoking as a risk factor for serious cardiovascular adverse events Nicotine replacement / NRT patches do not share the same combustion-product CYP induction as cigarettes Clinical action / document smoking status at every visit

It also tasked countries to implement the WHO Convention on Tobacco Control, which includes raising taxes to reduce the demand for the product

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