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For example, the leakage of nicotine from the cigarette filter is more during the rain, and also littering the cigarette filter into the river or the sea will lead to more PAHs leakage from it 35,36

However, current genetics-based evidence is lacking for elucidating the carcinogenic mechanisms of cigarette smoking-associated cancers, which leads many researchers to focus on the function of smoking-associated DNA methylation (SA-DNAm)

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And when we talked to healthcare professionals across multiple cancer centers, we repeatedly heard that people dont feel like they have time to add tobacco cessation programs to their routine practice. The Cancer Moonshot-funded Cancer Center Cessation Initiative (C3I) was created in 2017 to change that by providing support for National Cancer Institute-designated cancer centers integrating tobacco treatment into routine care

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