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Marijuanas biggest risk, Jon Caulkins of Carnegie Mellon University previously told me, is dependency and loss of productivity: At some level, we know that spending more than half of your waking hours intoxicated for years and years on end is not increasing the likelihood that youll win a Pulitzer Prize or discover the cure for cancer. But this is a fairly abstract risk one that affects a minority of pot users

It reshaped product design, consumer behavior and channel economics, helping drive the categorys rapid global expansion after 2020

E-cigarettes are a particular issue for teens

It is also the leading cause of cancer deaths in the United States