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Nationally, lifetime PCP use among individuals aged 12 and older was about 2.1% in 2023, down from 2.3% in prior years, with an estimated 5.9 million people reporting lifetime use, according to the Drug Enforcement Administration (2025)

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For instance, certain SNPs related to smoking initiation may modulate the rate of nicotine metabolism, affecting an individuals level of tobacco exposure and consequently increasing the toxic burden on the liver

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