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In some cases, provinces and territories have legislation prohibiting possession or transport of specific invasive species and species that can carry diseases

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This design was selected because the estimate of within-arm standard deviation (SD) from the external pilot study had a wide confidence interval and the interim analysis would allow for a more accurate estimation of the SD as a basis for assessing whether the expected effect size could be feasibly demonstrated

He did not actively participate at this point, and on 17 February 1581 he was granted leave of absence "for certain his necessary business in the service of Her Majesty"

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