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26 Additionally, it has been found that external cholesterol may alter the sensitivity to CSE-induced airway epithelial cell inflammation by regulating the STARD3-MFN2 pathway, cholesterol redistribution, changing cholesterol transport and accumulation, the activity of lipid transport regulators, and mitochondrial function and dynamics

A limitation of existing (predominantly cross-sectional) studies of e-cigarette use and health outcomes is bias due to the presence of participants whose respiratory symptoms preceded EC use [19]