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Squamous cell carcinoma usually occurs in the upper portion of the esophagus while adenocarcinoma (cancer in glands that produce mucus) typically occurs in the lower portion
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In addition, exposure to tobacco smoke extract (TSE) exposure can cause human macrophages to release EVs (including exosomes and ectosomes), which contribute to the release of matrix metalloproteinase 14 (MMP14) and may contribute to emphysema [102, 103]
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