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In vitro experiments have shown that tobacco smoke extract activates the MAPK/AP-1 signaling pathway and promotes aberrant proliferation of urothelial cells 23 , while nicotine contributes to tumor progression and chemoresistance through activation of the PI3K/AKT/mTOR signaling axis 24
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[3] [4] [5] [6] However, researchers emphasize that these findings reflect associations observed in cross-sectional or survey-based analyses
Users labelled the stunt as "sick" and called for action to be taken against the zoo
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