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While UB cigarette provided the most rapid UTS relief within the first 15 min of use, Velo Mini Pouch products demonstrated comparable or greater UTS relief over a longer period (4 h) relative to NRT gum

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While at the inception of the Lotus Project, pouch products' users were expected to graduate to the higher nicotine brands of loose MST, Skoal and Copenhagen, [13, 33] over time pouch product variants of higher nicotine MST have also been introduced, including large size pouches of Skoal, Grizzly, and Copenhagen (Table 1)

This classification was identical to that of the previous studies that investigated smoking behavior using the same investigative tools [16, 17, 26]