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In one study, the cytotoxicity of cigarette smoke extract (CSE) containing nicotine (CSE-N) and nicotine-free portion (CSE-O) on human bronchial epithelial cells was studied (BEAS-2B)

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Outstanding question were resolved by additional searches, or via corroborating evidence from external sources, such as advertising archives like Trinkets and Trash, general internet searches, company annual reports, investors webcasts and trade press including Tobacco Reporter (19712015), Convenience Store News (20042015), and Smokeshop Magazine (20032015)

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