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Bedaquiline does not induce or inhibit major CYP isoenzymes, namely, CYP1A2, CYP2C9, CYP2C19, or CYP2D6 at clinically relevant concentrations, minimizing the risk of CYP450-related interactions (Mesens et al., 2010)
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Substantial residual confounding would markedly reduce the log HR 22
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