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Hosakote YM, Jantzi PD, Esham DL, Spratt H, Kurosky A, et al

There is growing evidence through the use of animal xenograft models and cell culture systems, that (1) nicotine's carcinogenic role stems from multiple signaling mechanisms, primarily involving both non-receptor-mediated actions and receptor-mediated effects, including nicotinic acetylcholine receptors, -adrenergic receptors and epidermal growth factor receptors, as well as transforming growth factor receptors

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It has a leading market position in more than 50 countries and operates in some 180 countries