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The two most commonly used models, for in vivo exposure studies in rodents, to examine the effects of smoking and vaping, rely on systems designed to allow nose-only (NO) or whole-body (WB) exposures to smoke or ENDS aerosols

Ethics approval and consent to participate The study protocol was approved by the local Ethics Committee of Ruhr-University Bochum (ethical approval number: 20110512) and the University Siegen (ethical approval number: LS_ER_77) and was conducted in accordance with the Declaration of Helsinki and Good Clinical Practice guidelines

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doi:10.3390/ijms21186581 5