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Discussion This study on a cohort of 75 molecularly proven cEDS patients aimed to validate the revised diagnostic criteria and explore the multisystemic involvement of the disorder by comparing types and incidences of the numerous clinical manifestations at different ages and with those observed in other EDS subtypes, in order to delineate natural history and assist differential diagnosis

The number of these suppressive cells also tracked with how much the patient had smoked over their lifetime

Loneliness can contribute to physical frailty [6]

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