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Methods GWASs of DSM-NicDep We performed meta-analyses of GWASs of DSM-defined nicotine dependence (hereafter referred to as DSM-NicDep) across a total of 18 cohorts, 3 of which included samples of multiple ancestries, using a sample size-weighted meta-analysis implemented in METAL (Willer, Li, & Abecasis, Reference Willer, Li and Abecasis2010)

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