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Abbreviations AGE Advanced glycation end products AZA 5-Aza-2-deoxycytidine ADRB1 Adrenoceptor beta 1 BRD4 Bromodomain containing 4 C group Control group COPD Chronic obstructive pulmonary disease CS Cigarette smoke CSE Cigarette smoke extract CDS Coding DNA sequence Cpt1a Carnitine palmitoyl transferase 1a COX II Cytochrome c oxidase subunit II CDKN3 Cyclin-dependent kinase inhibitor 3 ERK Extracellular signal-regulated kinase EXs Exosomes EVs Extracellular vesicles E group Experiment group EndMT Endothelial-to-mesenchymal FOXA2 Fork head box protein A2 FAO Fatty acids H3K4me3 Tri-methylation of H3K4 H3R2me2a Asymmetric di-methylation of histone H3 arginine 2 HPMECs Human pulmonary microvascular endothelial cells HUVECs Human umbilical vein endothelial cells HLMVECs Human lung microvascular endothelial cells HPVECs Human pulmonary vascular endothelial cell HPAECs Human pulmonary artery endothelial cells ICS Inhaled corticosteroid

1 in Australia, and No

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