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"Smoking does terrible things not only to the body but also to the brain, and in some parts, disproportionately more than others." The regions most affected by smoking are the frontal cortex (involved in executive function, memory input and mood), cerebellum (coordination), corpus callosum (information bridge between the two hemispheres), and amygdala (emotional response and memory), Osborn pointed out

These holes cause the smoker and the smoke machine to inhale extra air

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Effect of Cyp2d6 and Cyp2c9 genotypes on fluoxetine and Norfluoxetine plasma concentrations during steady-state conditions