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Unlike tinctures (which you ingest) or vapes (which use aerosols), prerolls deliver cannabinoids and terpenes via inhalation often producing faster onset of effects

This shift is consistent with both age-related immune remodeling and with the immune alterations observed in people who smoke

Seitz, Matt Zoller (May 25, 1995)

Does Smoking Thin Your Blood

People with the following conditions should speak with a healthcare professional before using nicotine products: High blood pressure (hypertension) Heart disease Previous heart attack Stroke history Irregular heartbeat Pregnancy Nicotine may complicate cardiovascular management, particularly when blood pressure is already difficult to control