The toxins in cigarette smoke increase the fatty deposits (plaque) in the arteries. Plaque is sticky, making arteries narrow and less efficient

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Arch Phys Med Rehabil 103(9):17381748 Egbert RC, Bouck TT, Gupte NN, Pena MM, Dang KH, Ornell SS, Zelle BA (2020) Hypoalbuminemia and obesity in orthopaedic trauma patients: body mass index a significant predictor of surgical site complications
Cigar smokers are about 27 times more likely than nonsmokers to have oral cancer, 15 times more likely to have cancer of the esophagus and 53 times more likely to have cancer of the larynx, the ALA says
Here are brief introductions to each of the Big 4