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Nicotine increases oxidative stress, activates NF-kappa B and GRP78, induces apoptosis and sensitizes cells to genotoxic/xenobiotic stresses by a multiple stress inducer, deoxycholate: relevance to colon carcinogenesis

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There is evidence that its use is associated with certain cancers, diseases of the mouth and nicotine addiction, and long-term use may increase the risk of death from stroke. The researchers statistical analysis of participants data made adjustments for factors such as age, gender, cardiovascular disease diagnoses and body mass index