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[93] Continuous exposure to nicotine can cause an increase in the number of nicotinic receptors, which is believed to be a result of receptor desensitization and subsequent receptor upregulation

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[66] Some studies have suggested that they are more addictive

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Originally, CBD cigarette was used as a synonym for CBD pre-rolls, cone-shaped smokables filled with ground hemp flower (and sometimes kief), with no tobacco and no industrial fiber fill