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History [edit] Psychoactive drug use can be traced to prehistory

This biological link is supported by common underlying pathways, such as hepatic and systemic insulin resistance, atherogenic lipid profiles, hypertension, and increased expression of pro-atherogenic, pro-coagulant, and pro-inflammatory factors [75]

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Therefore, the upregulation of these genes by p53 possibly serves to sensitise cells to apoptosis by cytotoxic T cells and natural killer (NK) cells, which can express the ligands for death receptors