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Food and Drug Administration and Health Canada have deemed propylene glycol safe for human ingestion and topical application

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The latest, published in mBio , finds that e-cigarette users have a unique oral microbiomethe community of bacteria and other microorganismsthat is less healthy than nonsmokers but potentially healthier than cigarette smokers, and measures worsening gum disease over time

(Main sources: "The Global Cigarette: Origins and Evolution of British American Tobacco, 1880-1945" by Howard Cox, Oxford University Press, 2000