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Recent publications have reported, though, that it is the activation of the A2B receptor by adenosine that mediates production of pro-inflammatory, pro-fibrotic molecules, like interleukin-6, leading to chronic lung diseases, particularly pulmonary fibrosis (118, 132, 134, 135)

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These alternatives appeal to younger consumers and are often perceived as less harmful than traditional cigarettes, including clove cigarettes

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