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Smoking has been shown in large observational studies to be a dose-dependent risk factor for the diagnosis of bacterial vaginosis (BV) 8,9,10,11,12,13 , as well as significantly associated with risk of other genital infections in females including Trichomonas vaginalis 14 , herpes simplex virus type 2 (HSV-2) 15 and Chlamydia trachomatis 16,17