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The evidence that different smoking regimes have varied influences on both nicotine and TSNA levels in smoke (i.e., the International Organization of Standardization (ISO) protocol generates less nicotine and TSNAs compared to the Canadian Intense (CI) protocol) 27 implies these influences significantly alter the transfer of nicotine to the smoke, and may indicate why we do not observe a correlation between NNK/NNN and nicotine levels

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[35] In many jurisdictions, cigarillos and other cigars are taxed at lower rates than cigarettes, making them more appealing to low-income populations, including youth, young adults, and the unemployed

At the time, smoking was not known to be harmful, and companies capitalized on this with slogans like 'Just Like Dad.' Being seen as sophisticated and adult-like was a major cultural aspiration for children of that era

The more nicotine you ingest, the higher the amount of cotinine in your urine