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In cancer cells, the PI3K/Akt/mTOR pathway plays a crucial role in cell metabolism, growth, and motility and often results in increased uptake of glucose, heightened aerobic glycolysis (106), cell proliferation, autophagy, apoptosis, angiogenesis, and chemoresistance (182)

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THE THREE MUSKETEERS, Frank Morgan, Gene Kelly, Van Heflin, Gig Young, Robert Coote, 1948 ANCHORS AWEIGH, Frank Sinatra, Gene Kelly, Kathryn Grayson, 1945, winking THE PIRATE, Gene Kelly, Judy Garland, 1948 THE DEVIL MAKES THREE, Pier Angeli, Gene Kelly, 1952 CHRISTMAS HOLIDAY, Gene Kelly, Deanna Durbin, 1944 AN AMERICAN IN PARIS, Gene Kelly, 1951 ON THE TOWN, from left, Gene Kelly, Frank Sinatra, Jules Munshin, 1949 THE HAPPY ROAD, Gene Kelly, Barbara Laage, 1957 SINGIN' IN THE RAIN, Gene Kelly, 1952 SINGIN' IN THE RAIN, Debbie Reynolds, Gene Kelly, Jean Hagen, Donald O'Connor, 1952 ANCHORS AWEIGH, from left: Dean Stockwell, Frank Sinatra, Gene Kelly, 1945 THE THREE MUSKETEERS, Gene Kelly, June Allyson, 1948 THE CROSS OF LORRAINE, Hume Cronyn, Joseph Calleia, Gene Kelly, 1943 ANCHORS AWEIGH, Gene Kelly, 1945 THE THREE MUSKETEERS, Van Heflin, Gene Kelly, 1948 THE DEVIL MAKES THREE, Claus Clausen, Pier Angeli, Gene Kelly, 1952 LIVING IN A BIG WAY, Gene Kelly, Phyllis Thaxter, 1947 WHAT A WAY TO GO!, from left, Gene Kelly, Shirley MacLaine, 1963, TM & Copyright 20th Century Fox Film Corp

Also contributing to less smoking were bans on TV advertising, higher taxes on tobacco products, and smoke-free policies at work and in public places

In a survey of tobacco retailers in Dayton and Cleveland, Ohio (two cities in Tobacco Nation), nearly 70% of stores sold single cigarillos, little cigars, or blunts, with 87% of them advertising the products for less than $1, an accessible price point for cash-strapped youth