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The trend was particularly marked among female smokers aged 18 to 45, where the proportion who said they mainly or exclusively smoked hand-rolled cigarettes increased from 41% to 61%

The most common multi-morbid conditions include coronary artery disease, atrial fibrillation, congestive heart failure, skeletal muscle wasting, metabolic syndromes including diabetes mellitus, osteoporosis, depression, anxiety, gastro-esophageal reflux disease (GERD) and lung cancer [3]

Similar content being viewed by others Log in or create a free account to read this content Gain free access to this article, as well as selected content from this journal and more on nature.com or References Warnakulasuriya S, Johnson N W, Van Der Waal I

There is no cure for this condition

For the past few weeks I have been pouring over my old tobacco books trying to trace the origins of Cavendish