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Slotkin TA, MacKillop EA, Rudder CL, Ryde IT, Tate CA, Seidler FJ (2007) Permanent, sex-selective effects of prenatal or adolescent nicotine exposure, separately or sequentially, in rat brain regions: indices of cholinergic and serotonergic synaptic function, cell signaling, and neural cell number and size at 6 months of age

In addition, smoking further exacerbates endothelial dysfunction in individuals with hypertension, diabetes, dyslipidemia, and other coronary risk factors [45]

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What makes neurogenic ED especially complex is that it doesnt always behave the same way